Modern refrigerants have been developed to be more environmentally safe than many of the early chlorofluorocarbon-based refrigerants used in the early- and mid-twentieth century. These include HCFCs (R-22, as used in most U.S. homes before 2011) and HFCs (R-134a, used in most cars) have replaced most CFC use. HCFCs, in turn, are supposed to have been in the process of being phased out under the Montreal Protocol and replaced by HFCs such as R-410A, which lack chlorine. HFCs, however, contribute to climate change problems. Moreover, policy and political influence by corporate executives resisted change. Corporations insisted that no alternatives to HFCs existed. The environmental organization Greenpeace provided funding to a former East German refrigerator company to research an alternative ozone- and climate-safe refrigerant in 1992. The company developed a hydrocarbon mix of isopentane and isobutane, but as a condition of the contract with Greenpeace could not patent the technology, which led to its widespread adoption by other firms. Their activist marketing first in Germany led to companies like Whirlpool, Bosch, and later LG and others to incorporate the technology throughout Europe, then Asia, although the corporate executives resisted in Latin America, so that it arrived in Argentina produced by a domestic firm in 2003, and then finally with giant Bosch's production in Brazil by 2004.
In hot weather, air conditioning can prevent heat stroke, dehydration from excessive sweating and other problems related to hyperthermia. Heat waves are the most lethal type of weather phenomenon in developed countries. Air conditioning (including filtration, humidification, cooling and disinfection) can be used to provide a clean, safe, hypoallergenic atmosphere in hospital operating rooms and other environments where proper atmosphere is critical to patient safety and well-being. It is sometimes recommended for home use by people with allergies.